Longitudinal study revealing motor, cognitive and behavioral decline in a transgenic minipig model of Huntington's disease

• Main Authors: Monika Baxa (Author), Bozena Levinska (Author), Monika Skrivankova (Author), Matous Pokorny (Author), Jana Juhasova (Author), Jiri Klima (Author), Jiri Klempir (Author), Jan Motlı́k (Author), Stefan Juhas (Author), Zdenka Ellederova (Author)
• Format: Book
• Published: The Company of Biologists, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Huntington's disease (HD) is an inherited devastating neurodegenerative disease with no known cure to date. Several therapeutic treatments for HD are in development, but their safety, tolerability and efficacy need to be tested before translation to bedside. The monogenetic nature of this disor...