Umbelliferone and scopoletin target tyrosine kinases on fibroblast-like synoviocytes to block NF-κB signaling to combat rheumatoid arthritis

• Main Authors: Qilei Chen (Author), Wenmin Zhou (Author), Yueming Huang (Author), Yuanyang Tian (Author), Sum Yi Wong (Author), Wing Ki Lam (Author), Ka Yee Ying (Author), Jianye Zhang (Author), Hubiao Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is a complex autoimmune condition primarily affecting synovial joints, which targeted synthetic drugs have damaging safety issues. Saussurea laniceps, a reputed anti-rheumatic medicinal herb, is an excellent place to start looking for natural products as safe, effective, ta...