Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile sepsis Model

• Главные авторы: Sarah J Atkinson (Автор), Brian M Varisco (Автор), Mary Sandquist (Автор), Meghan N Daly (Автор), Lindsey Klingbeil (Автор), Joshua W Kuethe (Автор), Emily F Midura (Автор), Kelli Harmon (Автор), Amy Opoka (Автор), Patrick Lahni (Автор), Giovanna Piraino (Автор), Paul Hake (Автор), Basilia Zingarelli (Автор), Joel E Mortensen (Автор), James L Wynn (Автор), Hector R Wong (Автор)
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• Опубликовано: BMC, 2016-08-01T00:00:00Z.
• Предметы: article
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Abstract Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age influences the role of MMP8 in sepsis. First, we c...