Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile sepsis Model

• Main Authors: Sarah J Atkinson (Author), Brian M Varisco (Author), Mary Sandquist (Author), Meghan N Daly (Author), Lindsey Klingbeil (Author), Joshua W Kuethe (Author), Emily F Midura (Author), Kelli Harmon (Author), Amy Opoka (Author), Patrick Lahni (Author), Giovanna Piraino (Author), Paul Hake (Author), Basilia Zingarelli (Author), Joel E Mortensen (Author), James L Wynn (Author), Hector R Wong (Author)
• Format: Book
• Published: BMC, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age influences the role of MMP8 in sepsis. First, we c...