The Unexpected Anabolic Phenotype and Extended Longevity of Skin Fibroblasts after Chronic Glucocorticoid Excess

• Main Authors: Harris Pratsinis (Author), Stylianos Tsagarakis (Author), Irene Zervolea (Author), Dimitri Stathakos (Author), Nikos Thalassinos (Author), Dimitris Kletsas (Author)
• Format: Book
• Published: SAGE Publishing, 2006-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intense stress can challenge tissue homeostasis and accelerate the ageing process. However, several lines of evidence indicate that repeated mild stresses can have beneficial and even life-prolonging effects. Hypersecretion of glucocorticoids (GC) represents the major hormonal response to stress. Be...