Homozygous CREM-IbΔC-X Overexpressing Mice Are a Reliable and Effective Disease Model for Atrial Fibrillation

• Main Authors: Frank T. Stümpel (Author), Juliane Stein (Author), Kirsten Himmler (Author), Beatrix Scholz (Author), Matthias D. Seidl (Author), Boris V. Skryabin (Author), Frank U. Müller (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Atrial fibrillation (AF) is a significant cause of morbidity and mortality with foreseeably increasing prevalence. While large animal models of the disease are well established but resource intensive, transgenic AF mouse models are not yet widely used to develop or validate novel therape...