The R(−)-Enantiomer of Efonidipine Blocks T-type but Not L-type Calcium Current in Guinea Pig Ventricular Myocardium
In guinea pig ventricular cardiomyocytes, the R(−)-enantiomer of efonidipine concentration-dependently blocked T-type Ca2+ current with 85% inhibition at 1 μM. In contrast, R(−)-efonidipine (1 μM) had no effect on the L-type Ca2+ current and Ca2+ transient in cardiomyocytes and contractile force in...
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Main Authors: | Hikaru Tanaka (Author), Chisa Komikado (Author), Hideaki Shimada (Author), Kentaro Takeda (Author), Iyuki Namekata (Author), Toru Kawanishi (Author), Koki Shigenobu (Author) |
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Format: | Book |
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Elsevier,
2004-01-01T00:00:00Z.
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