Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer׳s disease

• Main Authors: Qian Guo (Author), Xiaoyao Zheng (Author), Peng Yang (Author), Xiaoying Pang (Author), Kang Qian (Author), Pengzhen Wang (Author), Shuting Xu (Author), Dongyu Sheng (Author), Liuchang Wang (Author), Jinxu Cao (Author), Wei Lu (Author), Qizhi Zhang (Author), Xinguo Jiang (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene therapy represents a promising treatment for the Alzheimer׳s disease (AD). However, gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have developed an siRNA nanocomplex able to be specifically delivered to the amyloid plaque...