Fetal acidosis in a sheep model: can we perform a second day of protocol in order to reduce the numbers of animals needed?

• Main Authors: C. Pierre (Author), L. Ghesquiere (Author), J. De Jonckheere (Author), E. Aubry (Author), D. Sharma (Author), P. Deruelle (Author), L. Storme (Author), V. Houfflin-Debarge (Author), C. Garabedian (Author)
• Format: Book
• Published: IMR Press, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To determine if a model of acidosis caused by occlusion of the umbilical cord could be repeated in the same sheep in ethicaly order to reduce the number of animals needed. Method: To obtain fetal acidosis, 1 min of total umbilical cord occlusion (UCO) every 2.5 min was performed on fetal...