Evidence‐based rationale for low dose nivolumab in critically ill patients with sepsis‐induced immunosuppression

• Auteurs principaux: Demy A. C. van denHaak (Auteur), Leila‐Sophie Otten (Auteur), Hans J. P. M. Koenen (Auteur), Ruben L. Smeets (Auteur), Berber Piet (Auteur), Peter Pickkers (Auteur), Matthijs Kox (Auteur), Rob ter Heine (Auteur)
• Format: Livre
• Publié: Wiley, 2023-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract A substantial part of critically ill patients suffer from sepsis‐induced immunosuppression. Reversal of immunosuppression through PD‐1 checkpoint inhibition has been proposed as a treatment strategy to overcome immunosuppression in these patients. The PD‐1 inhibitor nivolumab, currently use...