Solid Lipid Nanoparticles as Formulative Strategy to Increase Oral Permeation of a Molecule Active in Multidrug-Resistant Tuberculosis Management

• Main Authors: Antonella Obinu (Author), Elena Piera Porcu (Author), Sandra Piras (Author), Roberta Ibba (Author), Antonio Carta (Author), Paola Molicotti (Author), Rossana Migheli (Author), Alessandro Dalpiaz (Author), Luca Ferraro (Author), Giovanna Rassu (Author), Elisabetta Gavini (Author), Paolo Giunchedi (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The role of mycobacterial efflux pumps in drug-resistant tuberculosis has been widely reported. Recently, a new compound, named SS13, has been synthesized, and its activity as a potential efflux inhibitor has been demonstrated. In this work, the chemical-physical properties of the SS13 were investig...