Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain

• Main Authors: Taejin Kim (Author), Mathias Viard (Author), Kirill A. Afonin (Author), Kshitij Gupta (Author), Mary Popov (Author), Jacqueline Salotti (Author), Peter F. Johnson (Author), Charles Linder (Author), Eliahu Heldman (Author), Bruce A. Shapiro (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). However, the delivery of naked siRNAs is challenging becaus...