Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice

• Main Authors: Tetsuya Yokoyama (Author), Toyoshi Yanagihara (Author), Kunihiro Suzuki (Author), Naoki Hamada (Author), Kazuya Tsubouchi (Author), Saiko Ogata-Suetsugu (Author), Hironori Mikumo (Author), Chika Ikeda-Harada (Author), Takashige Maeyama (Author), Kazuyoshi Kuwano (Author), Yoichi Nakanishi (Author)
• Format: Book
• Published: BMC, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced pulmonary fibrosis that subsequently extended to alveolar cells at the a...