Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice

• Hauptverfasser: Tetsuya Yokoyama (Verfasst von), Toyoshi Yanagihara (Verfasst von), Kunihiro Suzuki (Verfasst von), Naoki Hamada (Verfasst von), Kazuya Tsubouchi (Verfasst von), Saiko Ogata-Suetsugu (Verfasst von), Hironori Mikumo (Verfasst von), Chika Ikeda-Harada (Verfasst von), Takashige Maeyama (Verfasst von), Kazuyoshi Kuwano (Verfasst von), Yoichi Nakanishi (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2017-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced pulmonary fibrosis that subsequently extended to alveolar cells at the a...