Perampanel increases seizure threshold in pentylenetetrazole-kindled mice and improves behavioral dysfunctions by modifying mRNA expression levels of BDNF/TrkB and inflammatory markers

• Main Authors: Nadia Perveen (Author), Faleh Alqahtani (Author), Waseem Ashraf (Author), Muhammad Fawad Rasool (Author), Syed Muhammad Muneeb Anjum (Author), Iram Kaukab (Author), Tanveer Ahmad (Author), Saleh A. Alqarni (Author), Imran Imran (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Perampanel (PER), a novel 3rd-generation antiseizure drug that modulates altered post-synaptic glutamatergic storming by selectively inhibiting AMPA receptors, is recently approved to treat intractable forms of seizures. However, to date, presumably consequences of long-term PER therapy on the comor...