Target-responsive subcellular catabolism analysis for early-stage antibody-drug conjugates screening and assessment

• Main Authors: Hua Sang (Author), Jiali Liu (Author), Fang Zhou (Author), Xiaofang Zhang (Author), Jingwei Zhang (Author), Yazhong Liu (Author), Guangji Wang (Author), Hui Ye (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Events including antibody‒antigen affinity, internalization, trafficking and lysosomal proteolysis combinatorially determine the efficiency of antibody-drug conjugate (ADC) catabolism and hence the toxicity. Nevertheless, an approach that conveniently identifies proteins requisite for payload releas...