Combining Co-Amorphous-Based Spray Drying with Inert Carriers to Achieve Improved Bioavailability and Excellent Downstream Manufacturability

• मुख्य लेखकों: Yingxi Zhang (लेखक), Yuan Gao (लेखक), Xiaoxiao Du (लेखक), Rou Guan (लेखक), Zhonggui He (लेखक), Hongzhuo Liu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

It is crucial to improve poorly water-soluble orally administered drugs through both preclinical and therapeutic drug discovery. A co-amorphous formulation consisting of two low molecular weight (MW) molecules offers a solubility/dissolubility advantage over its crystalline form by maintaining their...