Combining Co-Amorphous-Based Spray Drying with Inert Carriers to Achieve Improved Bioavailability and Excellent Downstream Manufacturability

• Päätekijät: Yingxi Zhang (Tekijä), Yuan Gao (Tekijä), Xiaoxiao Du (Tekijä), Rou Guan (Tekijä), Zhonggui He (Tekijä), Hongzhuo Liu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2020-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

It is crucial to improve poorly water-soluble orally administered drugs through both preclinical and therapeutic drug discovery. A co-amorphous formulation consisting of two low molecular weight (MW) molecules offers a solubility/dissolubility advantage over its crystalline form by maintaining their...