Quantification of Pharmacokinetic Profiles of PD-1/PD-L1 Antibodies by Validated ELISAs

• Auteurs principaux: Sara Zalba (Auteur), Ana M. Contreras-Sandoval (Auteur), Eva Martisova (Auteur), Reno Debets (Auteur), Christian Smerdou (Auteur), María Jesús Garrido (Auteur)
• Format: Livre
• Publié: MDPI AG, 2020-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Immunotherapy has changed the paradigm of cancer treatments. In this way, several combinatorial strategies based on monoclonal antibodies (mAb) such as anti (a)-PD-1 or anti (a)-PD-L1 are often reported to yield promising clinical benefits. However, the pharmacokinetic (PK) behavior of these mAbs is...