Quantification of Pharmacokinetic Profiles of PD-1/PD-L1 Antibodies by Validated ELISAs

• Main Authors: Sara Zalba (Author), Ana M. Contreras-Sandoval (Author), Eva Martisova (Author), Reno Debets (Author), Christian Smerdou (Author), María Jesús Garrido (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2020-06-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Immunotherapy has changed the paradigm of cancer treatments. In this way, several combinatorial strategies based on monoclonal antibodies (mAb) such as anti (a)-PD-1 or anti (a)-PD-L1 are often reported to yield promising clinical benefits. However, the pharmacokinetic (PK) behavior of these mAbs is...