Industrial-Scale Preparation of a Key Intermediate for the Manufacture of Therapeutic SGLT2 Inhibitors

Abstract (3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-methyltetrahydro-2H-pyran-2-one (1) is a key intermediate for the preparation of promising SGLT2 inhibitors currently undergoing clinical tests for diabetes therapy. However, fewer reports have demonstrated the preparation of compound 1 at an industrial...

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Main Authors: Lei Huang (Author), Yi Zhang (Author), Xiao-Hui Shan (Author), Yu Liu (Author), Jian-Qi Li (Author)
Format: Book
Published: Georg Thieme Verlag KG, 2022-12-01T00:00:00Z.
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