Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

• Главные авторы: Pimthanya Wanichawan (Автор), Jonas Skogestad (Автор), Marianne Lunde (Автор), Thea Parsberg Støle (Автор), Maria Stensland (Автор), Tuula A. Nyman (Автор), Ivar Sjaastad (Автор), Ole M. Sejersted (Автор), Jan Magnus Aronsen (Автор), Cathrine Rein Carlson (Автор)
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• Опубликовано: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Предметы: article
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The cardiac sodium-calcium exchanger (NCX1) is important for normal Na+- and Ca2+-homeostasis and cardiomyocyte relaxation and contraction. It has been suggested that NCX1 activity is reduced by phosphorylated phospholemman (pSer68-PLM); however its direct interaction with PLM is debated. Disruption...