Anti-Cocaine IgA Rather Than IgG Mediates Vaccine Protection from Cocaine Use

• Main Authors: Thomas R. Kosten (Author), Colin N. Haile (Author), Coreen B. Domingo (Author), Elizabeth B. Norton (Author)
• Formato: Libro
• Publicado: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

In developing a vaccine for fentanyl use disorder, we observed that IgA was the best correlate of vaccine-mediated protection from injected drug challenge, rather than IgG or binding affinity. Recent evidence shows that IgA secreting cells line the blood-brain barrier that capture pathogens and coul...