Suppressors of Cytokine Signaling (SOCS)1 and SOCS3 Proteins Are Mediators of Interleukin-10 Modulation of Inflammatory Responses Induced by Chlamydia muridarum and Its Major Outer Membrane Protein (MOMP) in Mouse J774 Macrophages

• Auteurs principaux: Skyla A. Duncan (Auteur), Rajnish Sahu (Auteur), Saurabh Dixit (Auteur), Shree R. Singh (Auteur), Vida A. Dennis (Auteur)
• Format: Livre
• Publié: Hindawi Limited, 2020-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The immunopathology of chlamydial diseases is exacerbated by a broad-spectrum of inflammatory mediators, which we reported are inhibited by IL-10 in macrophages. However, the chlamydial protein moiety that induces the inflammatory mediators and the mechanisms by which IL-10 inhibits them are unknown...