Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice

• Main Authors: Muhammad K. K. Niazi (Author), Nimit Dhulekar (Author), Diane Schmidt (Author), Samuel Major (Author), Rachel Cooper (Author), Claudia Abeijon (Author), Daniel M. Gatti (Author), Igor Kramnik (Author), Bulent Yener (Author), Metin Gurcan (Author), Gillian Beamer (Author)
• Format: Book
• Published: The Company of Biologists, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible humans. Here, we infected Diversity Outbred (DO) mice with ∼100 bacilli by aerosol to model responses in a highly heterogeneous population. Following infection, 'supersusceptible', 'susceptible' an...