Pipersentan: A De Novo Synthetic Endothelin Receptor Antagonist that Inhibits Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension

• Main Authors: Zeyu Zhang (Author), Chunlei Liu (Author), Yongyi Bai (Author), Xin Li (Author), Xiaojian Gao (Author), Chen Li (Author), Ge Guo (Author), Si Chen (Author), Mingzhuang Sun (Author), Kang Liu (Author), Yang Li (Author), Kunlun He (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Although major advances have been made in the pathogenesis and management of pulmonary arterial hypertension (PAH), the endothelin system is still considered to play a vital role in the pathology of PAH due to its vasoconstrictive action. Endothelin receptor antagonists (ERAs), either as...