Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models

• Main Authors: Kurt Reynolds (Author), Priyanka Kumari (Author), Lessly Sepulveda Rincon (Author), Ran Gu (Author), Yu Ji (Author), Santosh Kumar (Author), Chengji J. Zhou (Author)
• Format: Book
• Published: The Company of Biologists, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diverse signaling cues and attendant proteins work together during organogenesis, including craniofacial development. Lip and palate formation starts as early as the fourth week of gestation in humans or embryonic day 9.5 in mice. Disruptions in these early events may cause serious consequences, suc...