Sodium alginate and naloxone loaded macrophage-derived nanovesicles for the treatment of spinal cord injury

• Main Authors: Xiaoyao Liu (Author), Xue Jiang (Author), Qi Yu (Author), Wenwen Shen (Author), He Tian (Author), Xifan Mei (Author), Chao Wu (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Spinal cord injury (SCI) causes Ca2+ overload, which can lead to inflammation and neuronal apoptosis. In this study, we prepared a nanovesicle derived from macrophage membrane (MVs), which encapsulated sodium alginate (SA) and naloxone (NAL) to inhibit inflammation and protect neurons by reducing th...