Effect of paternal aging and vitrification on mitochondrial DNA copy number and telomere length of mouse blastocysts

• Main Authors: Nao ABURADA (Author), Jun ITO (Author), Yuki INOUE (Author), Taiyo YAMAMOTO (Author), Masamune HAYASHI (Author), Noko TERAMOTO (Author), Yuri OKADA (Author), Yuichi KOSHIISHI (Author), Koumei SHIRASUNA (Author), Hisataka IWATA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we examined the effects of paternal aging on the mitochondrial DNA copy number (mt-cn), telomere length (TL), and gene expression in mouse embryos. The effects of vitrification on the mt-cn and TL of the embryos derived from young and aged male parents (YF and AF, respectively) were e...