Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway

• Main Authors: Jinlian Wei (Author), Xin Chen (Author), Yongyun Li (Author), Ruoxi Li (Author), Keting Bao (Author), Liang Liao (Author), Yuqing Xie (Author), Tiannuo Yang (Author), Jin Zhu (Author), Fei Mao (Author), Shuaishuai Ni (Author), Renbing Jia (Author), Xiaofang Xu (Author), Jian Li (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Conjunctival melanoma (CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B (CuB). We found that CuB remarkably inhibited the proliferation of CM cells including CM-AS16, CRMM1, CRMM2 and CM2005....