Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo.

• Main Authors: Ernest J Mui (Author), Guy A Schiehser (Author), Wilbur K Milhous (Author), Honghue Hsu (Author), Craig W Roberts (Author), Michael Kirisits (Author), Stephen Muench (Author), David Rice (Author), J P Dubey (Author), Joseph W Fowble (Author), Pradipsinh K Rathod (Author), Sherry F Queener (Author), Susan R Liu (Author), David P Jacobus (Author), Rima McLeod (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toxoplasma gondii causes substantial morbidity, mortality, and costs for healthcare in the developed and developing world. Current medicines are not well tolerated and cause hypersensitivity reactions. The dihydrotriazine JPC-2067-B (4, 6-diamino-1, 2-dihydro-2, 2-dimethyl-1-(3'(2-chloro-, 4-tr...