Chemically modified small interfering RNA targeting Hedgehog signaling pathway for rheumatoid arthritis therapy

Rheumatoid arthritis (RA) is an inflammatory disease that leads to disability; however, existing therapies are still unsatisfactory. Activated fibroblast-like synoviocytes (FLSs) play an essential role in synovitis formation and joint destruction in RA. The Hedgehog signaling pathway is aberrantly a...

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Main Authors: Lang Lin (Author), Shangling Zhu (Author), Hongyu Huang (Author), Lin-Ping Wu (Author), Jianlin Huang (Author)
Format: Book
Published: Elsevier, 2023-03-01T00:00:00Z.
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