Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression

• Main Authors: Robert F Place (Author), Ji Wang (Author), Emily J Noonan (Author), Rachel Meyers (Author), Muthiah Manoharan (Author), Klaus Charisse (Author), Rick Duncan (Author), Vera Huang (Author), Xiaoling Wang (Author), Long-Cheng Li (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Application of RNA interference (RNAi) in the clinic has improved with the development of novel delivery reagents (e.g., lipidoids). Although RNAi promises a therapeutic approach at silencing gene expression, practical methods for enhancing gene production still remain a challenge. Previously, we re...