Propionate‐producing engineered probiotics ameliorated murine ulcerative colitis by restoring anti‐inflammatory macrophage via the GPR43/HDAC1/IL‐10 axis

• Main Authors: Guangbo Kang (Author), Xiaoli Wang (Author), Mengxue Gao (Author), Lina Wang (Author), Zelin Feng (Author), Shuxian Meng (Author), Jiahao Wu (Author), Zhixin Zhu (Author), Xinran Gao (Author), Xiaocang Cao (Author), He Huang (Author)
• Format: Book
• Published: Wiley, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Inflammatory bowel disease (IBD) is a chronic and unspecific inflammatory disorder of the gastrointestinal tract, and current treatment options often fail to maintain long‐term remission. Studies have shown that propionate level is reduced in fecal samples from patients with IBD. Propionate...