REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study

• Main Authors: Sara De Martin (Author), Daniela Gabbia (Author), Franco Folli (Author), Francesco Bifari (Author), Paolo Fiorina (Author), Nicola Ferri (Author), Stephen Stahl (Author), Charles E. Inturrisi (Author), Marco Pappagallo (Author), Sergio Traversa (Author), Paolo L. Manfredi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brain-derived neurotrophic factor (BDNF), a neurotrophin widely expressed in the central nervous system, exhibits important effects on neural plasticity. BDNF has been implicated in the mechanism of action of ketamine, a N-methyl-d-aspartic acid receptor (NMDAR) antagonist with rapid anti-depressant...