Practical Guide for Quantification of In Vivo Degradation Rates for Therapeutic Proteins with Single-Cell Resolution Using Fluorescence Ratio Imaging

Many tools for studying the pharmacokinetics of biologics lack single-cell resolution to quantify the heterogeneous tissue distribution and subsequent therapeutic degradation in vivo. This protocol describes a dual-labeling technique using two near-infrared dyes with widely differing residualization...

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Hoofdauteurs: Ian Nessler (Auteur), Cornelius Cilliers (Auteur), Greg M. Thurber (Auteur)
Formaat: Boek
Gepubliceerd in: MDPI AG, 2020-02-01T00:00:00Z.
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