MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC

• मुख्य लेखकों: Renumathy Dhanasekaran (लेखक), Jangho Park (लेखक), Alekesey Yevtodiyenko (लेखक), David I. Bellovin (लेखक), Stacey J. Adam (लेखक), Anand Rajan KD (लेखक), Meital Gabay (लेखक), Hanan Fernando (लेखक), Julia Arzeno (लेखक), Vinodhini Arjunan (लेखक), Sergei Gryanzov (लेखक), Dean W. Felsher (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce rapid and sustained tumor regression, a phenomenon...