Identification of a potent dual-function inhibitor for hIMPDH isoforms by computer-aided drug discovery approaches

• Päätekijät: Meysam Yazdani (Tekijä), Javad Zamani (Tekijä), Seyed Safa-Ali Fatemi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in de novo biosynthesis of purine nucleotides. Due to this important role, it is a great target to drug discovery for a wide range of activities, especially immunosuppressant in heart and kidney transplantation. Both human IMPDH isoforms ar...