A spatially specified systems pharmacology therapy for axonal recovery after injury

• Main Authors: Mustafa M. Siddiq (Author), Nicholas P. Johnson (Author), Yana Zorina (Author), Arjun Singh Yadaw (Author), Carlos A. Toro (Author), Jens Hansen (Author), Vera Rabinovich (Author), Sarah M. Gregorich (Author), Yuguang Xiong (Author), Rosa E. Tolentino (Author), Sari S. Hannila (Author), Ehud Kaplan (Author), Robert D. Blitzer (Author), Marie T. Filbin (Author), Christopher P. Cardozo (Author), Christopher L. Passaglia (Author), Ravi Iyengar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that regulates multiple subcellular processes in the...