Intranasal delivery of paeoniflorin nanocrystals for brain targeting

• Main Authors: Chaoyin Wu (Author), Benyue Li (Author), Yi Zhang (Author), Tingting Chen (Author), Chuangrong Chen (Author), Wei Jiang (Author), Qi Wang (Author), Tongkai Chen (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paeoniflorin (PA) is an anti-Parkinson Chinese medicine with inferior bioavailability and difficulty in delivery to the brain. This research is to develop an efficacious PA nanocrystal formulation (PA-NCs) that is suitable for intranasal administration to treat Parkinson's disease (PD). PA-NCs...