Accelerating Development of Benziamidazole-Class Proton Pump Inhibitors: A Mechanism-Based PK/PD Model to Optimize Study Design with Ilaprazole as a Case Drug

• Prif Awduron: Ranran Jia (Awdur), Fan Zhang (Awdur), Ni Wu (Awdur), Wen Xu (Awdur), Huitao Gao (Awdur), Bo Liu (Awdur), Hongyun Wang (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2021-03-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Proton pump inhibitors (PPIs) are the mainstay for treatment of acid-related diseases. This study developed a mechanism-based pharmacokinetic (PK) and pharmacodynamics (PD) model with ilaprazole as case drug, so as to support and accelerate the development of novel PPIs. The model was established an...