Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia

• Prif Awduron: Catherine Hambly (Awdur), Jacqueline S. Duncan (Awdur), Zoë A. Archer (Awdur), Kim M. Moar (Awdur), Julian G. Mercer (Awdur), John R. Speakman (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: The Company of Biologists, 2012-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

SUMMARY The causes of post-restriction hyperphagia (PRH) represent a target for drug-based therapies to prevent obesity. However, the factors causing PRH are poorly understood. We show that, in mice, the extent of PRH was independent of the time under restriction, but depended on its severity, sugge...