Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia

• Main Authors: Catherine Hambly (Author), Jacqueline S. Duncan (Author), Zoë A. Archer (Author), Kim M. Moar (Author), Julian G. Mercer (Author), John R. Speakman (Author)
• Format: Book
• Published: The Company of Biologists, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The causes of post-restriction hyperphagia (PRH) represent a target for drug-based therapies to prevent obesity. However, the factors causing PRH are poorly understood. We show that, in mice, the extent of PRH was independent of the time under restriction, but depended on its severity, sugge...