Light-Triggered Cellular Delivery of Oligonucleotides

• Main Authors: Leena-Stiina Kontturi (Author), Joep van den Dikkenberg (Author), Arto Urtti (Author), Wim E. Hennink (Author), Enrico Mastrobattista (Author)
• Format: Bog
• Udgivet: MDPI AG, 2019-02-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

The major challenge in the therapeutic applicability of oligonucleotide-based drugs is the development of efficient and safe delivery systems. The carriers should be non-toxic and stable in vivo, but interact with the target cells and release the loaded oligonucleotides intracellularly. We approache...