A physiologically‐based pharmacokinetic/pharmacodynamic modeling approach for drug-drug‐gene interaction evaluation of S‐warfarin with fluconazole

• Main Authors: Kuo Geng (Author), Chaozhuang Shen (Author), Xiaohu Wang (Author), Xingwen Wang (Author), Wenxin Shao (Author), Wenhui Wang (Author), Tao Chen (Author), Hua Sun (Author), Haitang Xie (Author)
• Format: Book
• Published: Wiley, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Warfarin is a widely used anticoagulant, and its S‐enantiomer has higher potency compared to the R‐enantiomer. S‐warfarin is mainly metabolized by cytochrome P450 (CYP) 2C9, and its pharmacological target is vitamin K epoxide reductase complex subunit 1 (VKORC1). Both CYP2C9 and VKORC1 have...