Further Evidence That Defects in Main Thyroid Dysgenesis-Related Genes Are an Uncommon Etiology for Primary Congenital Hypothyroidism in Mexican Patients: Report of Rare Variants in <i>FOXE1</i>, <i>NKX2-5</i> and <i>TSHR</i>

• Main Authors: Miguel Angel Alcántara-Ortigoza (Author), Iraís Sánchez-Verdiguel (Author), Liliana Fernández-Hernández (Author), Sergio Enríquez-Flores (Author), Aidy González-Núñez (Author), Nancy Leticia Hernández-Martínez (Author), Carmen Sánchez (Author), Ariadna González-del Angel (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mexico shows a high birth prevalence of congenital hypothyroidism (CH) due to thyroid dysgenesis (TD). <i>PAX8</i> defects underlie only 1% of these cases and <i>NKX2-1</i> does not seem to be involved. Here, we analyzed other TD-related genes in 128 non-related Mexican patie...