Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping

• Autors principals: Ana I. Loureiro (Autor), Carlos Fernandes‐Lopes (Autor), Maria João Bonifácio (Autor), Filipa Sousa (Autor), László E. Kiss (Autor), Patricio Soares‐da‐Silva (Autor)
• Format: Llibre
• Publicat: Wiley, 2022-02-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Abstract Opicapone (2,5‐dichloro‐3‐(5‐(3,4‐dihydroxy‐5‐nitrophenyl)‐1,2,4‐oxadiazol‐3‐yl)‐4,6‐dimethylpyridine 1‐oxide) is a selective catechol‐O‐methyltransferase inhibitor that has been granted marketing authorization in Europe, Japan, and United States. The present work describes the metabolism a...