Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping

• Main Authors: Ana I. Loureiro (Author), Carlos Fernandes‐Lopes (Author), Maria João Bonifácio (Author), Filipa Sousa (Author), László E. Kiss (Author), Patricio Soares‐da‐Silva (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Opicapone (2,5‐dichloro‐3‐(5‐(3,4‐dihydroxy‐5‐nitrophenyl)‐1,2,4‐oxadiazol‐3‐yl)‐4,6‐dimethylpyridine 1‐oxide) is a selective catechol‐O‐methyltransferase inhibitor that has been granted marketing authorization in Europe, Japan, and United States. The present work describes the metabolism a...