Saikosaponin-d Inhibits the Hepatoma Cells and Enhances Chemosensitivity Through SENP5-Dependent Inhibition of Gli1 SUMOylation Under Hypoxia

• Main Authors: Chun-Yan Zhang (Author), Zhong-Min Jiang (Author), Xiao-Fang Ma (Author), Yue Li (Author), Xiao-Zhi Liu (Author), Li-Li Li (Author), Wen-Han Wu (Author), Tao Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemosensitivity is one of the key factors affecting the therapeutic effect on cancer, but the clinical application of corresponding drugs is rare. Hypoxia, a common feature of many solid tumors, including hepatocellular carcinoma (HCC), has been associated with resistance to chemotherapy in part th...