Saikosaponin-d Inhibits the Hepatoma Cells and Enhances Chemosensitivity Through SENP5-Dependent Inhibition of Gli1 SUMOylation Under Hypoxia

• Autors principals: Chun-Yan Zhang (Autor), Zhong-Min Jiang (Autor), Xiao-Fang Ma (Autor), Yue Li (Autor), Xiao-Zhi Liu (Autor), Li-Li Li (Autor), Wen-Han Wu (Autor), Tao Wang (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Chemosensitivity is one of the key factors affecting the therapeutic effect on cancer, but the clinical application of corresponding drugs is rare. Hypoxia, a common feature of many solid tumors, including hepatocellular carcinoma (HCC), has been associated with resistance to chemotherapy in part th...