Viral load Reduction in SHIV-Positive Nonhuman Primates via Long-Acting Subcutaneous Tenofovir Alafenamide Fumarate Release from a Nanofluidic Implant

• Main Authors: Fernanda P. Pons-Faudoa (Author), Nicola Di Trani (Author), Antons Sizovs (Author), Kathryn A. Shelton (Author), Zoha Momin (Author), Lane R. Bushman (Author), Jiaqiong Xu (Author), Dorothy E. Lewis (Author), Sandra Demaria (Author), Trevor Hawkins (Author), James F. Rooney (Author), Mark A. Marzinke (Author), Jason T. Kimata (Author), Peter L. Anderson (Author), Pramod N. Nehete (Author), Roberto C. Arduino (Author), K. Jagannadha Sastry (Author), Alessandro Grattoni (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV-1 is a chronic disease managed by strictly adhering to daily antiretroviral therapy (ART). However, not all people living with HIV-1 have access to ART, and those with access may not adhere to treatment regimens increasing viral load and disease progression. Here, a subcutaneous nanofluidic impl...