Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6‐catalyzed metabolism of solanidine

• Main Authors: Robert Løvsletten Smith (Author), Birgit M. Wollmann (Author), Elisabet Størset (Author), Hasan Çağın Lenk (Author), Kevin S. O'Connell (Author), Marianne Kringen Kristiansen (Author), Magnus Ingelman‐Sundberg (Author), Espen Molden (Author)
• Format: Book
• Published: Wiley, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cytochrome P450 2D6 (CYP2D6) is important for metabolism of 20%-25% of all clinically used drugs. Many known genetic variants contribute to the large interindividual variability in CYP2D6 metabolism, but much is still unexplained. We recently described that nuclear factor 1B (NFIB) regulate...