On-line coupling of derivatization with pre-concentration to determine trace levels of methotrexate

• Main Authors: Samy Emara (Author), Tsutomu Masujima (Author), Walaa Zarad (Author), Maha Kamal (Author), Ramzia EL-Bagary (Author)
• Format: Book
• Published: Elsevier, 2013-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new simple, sensitive and precise green analytical procedure using an automated packed-reactor derivatization technique coupled with on-line solid-phase enrichment (SPEn) has been developed and evaluated to determine trace levels of methotrexate (MTX). The method was based on injection of MTX into...