Identification of trunk mutations in gastric carcinoma: a case study

• Main Authors: Zhan Zhou (Author), Shanshan Wu (Author), Jun Lai (Author), Yuan Shi (Author), Chixiao Qiu (Author), Zhe Chen (Author), Yufeng Wang (Author), Xun Gu (Author), Jie Zhou (Author), Shuqing Chen (Author)
• Format: Book
• Published: BMC, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Intratumor heterogeneity (ITH) poses an urgent challenge for cancer precision medicine because it can cause drug resistance against cancer target therapy and immunotherapy. The search for trunk mutations that are present in all cancer cells is therefore critical for each patient....