High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

• Main Authors: Serena Cappato (Author), Laura Tonachini (Author), Francesca Giacopelli (Author), Mario Tirone (Author), Luis J. V. Galietta (Author), Martina Sormani (Author), Anna Giovenzana (Author), Antonello E. Spinelli (Author), Barbara Canciani (Author), Silvia Brunelli (Author), Roberto Ravazzolo (Author), Renata Bocciardi (Author)
• Format: Book
• Published: The Company of Biologists, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive heterotopic endochondral ossification leading to...