Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner.

• Main Authors: Orhan Rasid (Author), Véronique Mériaux (Author), Erin M Khan (Author), Chloé Borde (Author), Ioana S Ciulean (Author), Catherine Fitting (Author), Bénédicte Manoury (Author), Jean-Marc Cavaillon (Author), Noëlle Doyen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A critical role for intracellular TLR9 has been described in recognition and host resistance to Leishmania parasites. As TLR9 requires endolysosomal proteolytic cleavage to achieve signaling functionality, we investigated the contribution of different proteases like asparagine endopeptidase (AEP) or...