Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner.

• मुख्य लेखकों: Orhan Rasid (लेखक), Véronique Mériaux (लेखक), Erin M Khan (लेखक), Chloé Borde (लेखक), Ioana S Ciulean (लेखक), Catherine Fitting (लेखक), Bénédicte Manoury (लेखक), Jean-Marc Cavaillon (लेखक), Noëlle Doyen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2016-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A critical role for intracellular TLR9 has been described in recognition and host resistance to Leishmania parasites. As TLR9 requires endolysosomal proteolytic cleavage to achieve signaling functionality, we investigated the contribution of different proteases like asparagine endopeptidase (AEP) or...