Elevated IgA and IL-10 levels in very-early-onset inflammatory bowel disease secondary to IL-10 receptor deficiency

• Main Authors: Natascha Silva Sandy (Author), Lia Furlaneto Marega (Author), Giane Dantas Bechara (Author), Adriana Gut Lopes Riccetto (Author), Carmen Bonfim (Author), Maria Marluce dos Santos Vilela (Author), Antonio Fernando Ribeiro (Author), Maria De Fatima Servidoni (Author), Elizete Aparecida Lomazi (Author)
• Format: Book
• Published: Sociedade de Pediatria de São Paulo, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT Objective: To report two patients with very-early-onset inflammatory bowel disease (VEOIBD) secondary to interleukin-10 receptor (IL-10R) mutations, explore immunophenotyping data and plasma cytokine profile on these cases compared to healthy controls, and describe the phenotype of IL-10/IL...